ea0010oc6 | Reproduction, neuroendocrinology and diabetes | SFE2005
Adams V
, Kola B
, Garcia E
, Hubina E
, Dalino P
, Khalaf S
, Grossman|M##Korbonits A
Cannabinoids and ghrelin are potent appetite stimulators. The ghrelin receptor (GHS-R1a), endocannabinoids and the cannabinoid 1 (CB1) receptor are expressed in the hypothalamus. There is evidence that the novel CB1 antagonist, rimonabant, causes weight loss by both central and peripheral effects. The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status and regulates the energy metabolism within the single cell but also at whole body level. We have shown p...